Recommended literature of synthetic biology: peroxisome metabolic coupling is combined into fatty alcohol

Summary
The efficient utilization and biotransformation of one-carbon compounds are the current research hotspots in the field of biomanufacturing. Among them, methanol can be prepared from CO2 in large quantities, so it is considered to be an environmentally friendly biomanufacturing raw material with potential. Due to the cytotoxicity of methanol and formaldehyde

Expert Review Nature | Yu Hongjun/Liu Xiaotian/Zhang Min Reveals Fungal Cell Wall β- The molecular basis of 1,3-glucan synthesis and the mechanism of resistance to echinococcin antifungal drugs

Reviews | Wang Linqi (Institute of Microbiology, Chinese Academy of Sciences), Huang Yihua (Institute of Biophysics, Chinese Academy of Sciences), Ni Ming (Tongji Hospital) Xi

Ten conjectures of synthetic biology in 2023

According to the "Synthetic Biology Industry Investment Report", from 2018 to 2022, China's synthetic biology primary market has completed a total of 1039 investment and financing events. This report specially invites ten industry professionals from academic institutions, industry and related social institutions to imagine and express their unique opinions from the perspectives of industry trends, breakthroughs in key technologies, and future products. From the underlying technology research to industrial applications, from our medical treatment to food, China's synthetic biology ecology is vibrant.

Huili Biology completed round A financing and added synthetic biology track

Recently, a new generation of synthetic biology enzyme computing design platform - Huili Biotech announced the completion of nearly 3 million yuan of Series A financing, jointly led by Legend Capital and Boyuan Capital, followed by Qianji Capital, Yunqi Capital and Zhongwei Capital, and Taihe Capital served as financial advisors. This round of financing will be used to accelerate the construction and operation of large-scale production facilities, the R&D of new product pipelines, and the expansion of talent teams.

Synthesis and Application of Pyrazine Carboxylic Acid - Research and Development Department: Wei Yongming

As an important pharmaceutical intermediate, pyrazinecarboxylic acid is widely used in the hypoglycemic drug glipizide and a new generation of long-acting hypolipidemic drug aximus, and its derivative methyl pyrazinecarboxylate is also an important drug for the treatment of tuberculosis. There are 3 main synthesis methods: 1. Chemical synthesis method: there are mainly 3 ways: 1) Potassium permanganate is used in the preparation of oxidation, chlorination, hydrolysis and re-oxidation, which has large pollution, poor product traits, and the yield is less than 20%. 2) Prepared by chlorination, acylation, hydrolysis and oxidation, the yield is less than 50%.

Huili Biology and Novozymes China have reached strategic cooperation to jointly promote the development of AI enabled neoplasm enzyme catalytic technology

Recently, Jiangsu Huili Biotechnology Co., Ltd. (hereinafter referred to as "Huili Biotechnology") and Novozymes (China) Investment Co., Ltd. (hereinafter referred to as "Novozymes China") officially signed a strategic cooperation agreement to form a long-term strategic partnership in the fields of industrial biocatalysis, pharmaceutical intermediates and APIs. At the ceremony, Mr. Ye Yang, CEO of Huili Biologics, and Mr. Ye Xiaofeng, Vice President of Agriculture and Industry of Novozymes China, signed the contract on behalf of both parties.

Exclusive interview with Huili Biotechnology, a cutting-edge synthetic biology team, building a computing platform for implementing enzyme scenario design in China, enabling rational design and modification of enzymes. The industrialization of multiple pro

Enzymes are ubiquitous catalysts in living organisms, which can efficiently and selectively catalyze various biochemical reactions under mild conditions, and subtly regulate extremely complex metabolic processes in living organisms. In the process of natural enzyme application to industrial catalytic technology, a lot of excavation, screening, design improvement and other work are required. In recent years, the design ideas of synthetic biology engineering and the emergence of a large number of new